Small Speakers For A Large Room...

I'm about to move my system into a much larger room - ~4,000 cu feet - but for domestic tranquility (I love my wife far more than my music) will need to keep the speakers on the small side. What options are out there in a large stand mount or slender floor standing speaker that work well in large room? I don't listen very loud, and will have a separate powered subwoofer, but mains that visually dominate the room are not an option for me.

If you know of small-ish speakers that sound large, I'd appreciate some suggestions!