I disagree with Leafs. I tried it both ways, and I prefer 2 separate runs of cable. I Compared a non-biwire setup, using Audioquest SA-40 full range, but connected to the high freq posts, and CV4 for the jumpers going to the bass posts, and a full biwire setup using SA-40 on the highs and CV4 for the low end. There was an appreciable difference. I have, in the past, used a large cable and run an internal biwire, which is only good for getting around the stock jumpers, since the wires are so close together. The wires for the lows and highs need to be separated by a couple of inches in order to alleviate the electrical field interaction. Notice that I wasnt merely comparing the stock jumpers to a better cable- I used the same cable for the jumpers as I did for the low end in the biwire setup, and I definately got a more dimensional soundstage, with more realistic sense of space. There are great cables that are fairly small in size, I agree with avgeorge-try it before you buy.