I wouldn't worry about it.
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There should be very little to worry about except for different amounts of packing on top vs bottom possibly resulting in physical damage, but you would see that, and increased potential for capacitor oil to leak. But most any tech should be able to check that for you unless opening the case invalidates whatever warranty there is. There may be other problems but I am not aware of them.
Do you really think UPS or Fed Ex or USPS pays any attention to the direction the arrows are pointing on a shipping box? In my experience, all these services are HARD on packages. I would have NO confidence that labelling and other instructions are followed during shipment; for all you know, your box was actually shipped UPRIGHT because UPS or whoever ignored the arrows pointing the wrong way. Sorry to be so cynical, but I have shipped and received many packages delivered upside down, sideways and everywhichway but loose.
The problem is that you don't know how hard the impacts were on the box at all. The heaviest thing in the amp are the transformer(s) and they could tear loose or bend the sheetmetal Then the thing would not play. I would not worry about it if it plays and isn't rattling or bent.
(I had a big ol' amp that fell to the floor from being carried and the frame WAS bent when the transformer tried to continue on it's path when the rest of the thing stopped at the floor. it played ok but the bend in the chassis was VERY evident)
I get a laugh (cry) everytime I visit my local FedEx Truck Depot to drop off a package. In the lobby there is a photo of one of their large sorting centers, probably the national hub in Memphis. I guess it's there as a way to show off their operation. Near the center of the photo there is a really large JVC Television box (probably a 32 or 35 inch set). It looks definitely like an OEM box (ie, its not Aunt Margaret sending her Christmas gifts.) Well the box is upside down. I wonder who at FedEx chose that picture; they must have been asleep.
I wouldn't be too quick to dismiss the potential of an upside down effect. I recall a mid-70's article in one of the Russian aerospace journals that referred to "capacitor confusion" resulting from quantum acceleration phonomena. Something about discontinuous gravitational fields. This may be one of the factors involved with "break-in". Anybody doing any controlled listening?