I have upgradded my 650's using Double Helix Audio cables. Very good sound. He knows Sennheisers.
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I've got the Senn HD600 and a cable upgrade made a very very significant improvement. The same would definitely hold for the HD650 too, since the differences between them are relatively minor. I used a Moon Audio Blue Dragon for $185, IIRC. Any of the premium cables will definitely improve the sound, e.g. Moon Audio, ALO, Cardas and others.
I'm a longtime fan of the HD650 for its coherent, non-fatiguing sound, and great value for the price. I've had most of the legendary headphones at one time or another. I've used the Equinox, Cardas, Blue Dragon, Silver Dragon, and Zu Mobius cables with the HD650. The Zu was the clear winner, and it wasn't even close. I currently use the 650 with the Equinox (it was what I could get at the time), and keep wishing it was the Zu cable (recheck every morning; nope, still a bloody Equinox) -- I've let a couple of those Zu's go and always regretted it later. The Zu is unique in that it does the following:
* boosts the treble & sparkle (the 650 needs it) without broaching the point of harsh or fatiguing
* doesn't dry up the 650's nice midrange, like pure silver seems to
* tightens up the bass without making it leaner in the process
* excellent, pinpoint imaging
All the other cables fail on 1 or more of those points.