Run length

Room layout dictates the sub is on the opposite wall. Not ready to run a wire across the floor. It would be 26 feet.

To skip the floor run I would have to go up and down inside the wall. That would add another 18 feet for a total of 44 feet.  Too long?  Will be using plain old 14AWG cord.
Why run a sub at all?? Are your speakers not good with bass? Ditch the speakers and the sub and buy speakers that do bass well.