Question regarding burn-in

I fear that this may be a stupid question, but I'm still a neophyte in the high-end world ...

If I want to burn in an interconnect between my preamp and power amp by playing a source for a number of continuous hours (24? 48? 96?), does the power amp need to be powered up?

Additionally, any suggestions on the burn-in process would be helpful. I've been looking for a reference article, but haven't found anything that provides much detail.

Thanks,

Martin