I believe all the drivers and crossover are different. I own Response 1SCs and Tablette 50 Signatures but have never had the chance to hear any of the Studio series.
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I have a pair of Studio 125 and also the Response 3.8 speakers. My 3.8's will be main fronts driven by Krell, and the 125's as rears driven by Rotel - Processed by Krell Showcase pre/pro. Up till now I've been powering them with a Rotel RMB-1095 amp (Krell FPB300cx is currently on order - cant wait!). The 125's are a fantastic speaker when compared to the 3.8 (I compared them both as main speakers running only two channels from the Rotel). The 125's lack the real low base, and the mid range is not quite as pronounced but against the 3.8's they're a great clean, detailed sounding entry level speaker. Room placement is critical, be sure to move them well into the room away from both rear and side walls. I found 3 meters apart between the speakers was best for soundstage. The 3.8 is just breathtaking, you only get what you pay for!