I have 2+2's and can tell you from experience that many amps can drive them without blowing up or sounding obviously wanting in any department. However, until you have tried several amps in rapid succession you won't appreciate how different each sounds, and therein lies the challenge.
I ran my 2+2 on the following: Macintosh MC7300, Acoustat TNT-200 (stock and later modded), Hafler 9505, and PS Audio HCA-2.
Each sounded great and could reach ear-splitting levels without breaking a sweat. But until I tried the TNT-200 I had no idea my Mac wasn't doing the bass region of the 2+2's justice. The TNT-200 had bass slam; the Mac didn't. The 9505 was even better in that department.
But I finally found contentment with the PS Audio HCA-2. It simply does everything well while being completely silent and cool.. the amp you just forget is there. I think if these class D amps had been around in the early 1980's when Acoustats hit the market they would have been a natural match. 25 years too late..!