Yes if you use a sub with high level inputs. You run these from the amps SPEAKER outputs. REL will do this, I think Hsu and others also.
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I should have added that this is for powered subs. It is possible also to buy or build a reduction device that converts the power output to line level to drive an amp for passive subs. I use this method with my older Hsu subs in my video set up. The powered sub approach is simpler and probably cheaper in long run.