I've used the Novus #2 product on CD's and DVD's to clean them and to stop a skip on CD's and DVD's. I have not experienced a problem doing so and it has cleaned and stopped the skip.
Good question and the best answer I can give you is I don't know. I've only used it on red Book CD's but I have used it on Blue Ray DVD's without causing any harm that I could detect while listening to music or watching the Blue Ray on a high definition 55" flat screen.
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