Yes Tholt it may. I replaced the caps in my pre and found moving my speakers was the final step to fine tuning. The new caps were much more alive and dynamic so speaker placement fine tuning was needed.
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There is, theoretically, a place in a room where speakers interface at an acoustic optimum. A computer program can help find those locations, but there are too many variables for the procedure to be absolutely perfect. Human hearing being what it is, we will want to final-tweak them to the location where our ears tell us that they sound best.
Once you find what seems, to your ears, to be the ideal location, it's probably best to do some extensive listening after each component change to allow your ears to adjust. Unless there has been a change in the acoustical environment of the room (by adding a piece of furniture, etc.), optimum speaker location really shouldn't change.
Rrog, I don't trust anyone else's ears but my own, as mine are the only ones that I can hear with. My initial question was more of a blanket statement -- does equipment change affect speaker placement? I honestly wasn't sure since my particular speaker placement method is based on bass resonance from the room. But I can see that if a component alters the bass, and the rest of the spectrum, perhaps one would need to address speaker placement. Thanks all so far for the insights. I have yet to receive the preamp yet, but it sounds like I may have to readjust the speakers, if only to find out that they were in the right place to begin with.