I use Etymotic ER-4P with my iPod Touch and they work well, the only issue is the bass is a little challenged. If you have the ER-4S then you may need an amp to drive them. There are a lot more in ear headphones available now (compared to when I got the ER-4Ps), none of which I've heard. I would suspect an over the ear headphone will require even more power than the ER-4P (or other in ear) so you may have serious degradation. I chose the ER-4P since they are so small, over the ear headphones are just too bulky for travel. I also don't know if the Nano has the same headphone driving capabilities as the Touch.
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