mixing and matching.....

I might be opening a can of worms on this one but with literally hundreds of posts on cables I can't resist. How many of us have a mixed bag of IC + PC cable mfrs on our systems? My system has cables from Audioquest, Pure-note, Homegrown (remember them?) and different model cables within each mfr. The situation with Power cables is even worse.

My question is this: How much benefit can any of this yield with such a hodge podge. Would it be better to get rid of everything and start anew with 1 mfr.? Has anyone had this problem?