If it all worked fine then went south, it sounds like an amp problem. I had a tube amp that started to thump on turn on and it needed to be sent in for repair. I would suspect the amp.
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OP I'm not trying to be a downer, but I lost a channel on my C2500 it is probably newer than that C50. I think I caused the problem though. I had a cable drop. It took out the poweramp right monoblock. 2 months later the right main 12AX7 (one of two) blew and took the channel with it on my C2500. Something to do with the auto bias.. BUT none the less Macs do mess up every now and then..Even if I did help it along.. :-(
You have a second set of XLRs to try out... I've had them mess up a few times also.. No spiders inside making a new home? :-) Take a peak..