To clarify for Ray, I use a V8 ultrasonic on used records, LAST mold-release agent with a microfiber brush on new records and LAST cleaning solution with an old-school Discwasher brush for cleaning everything that hits my tables before the styli get near them. I brush the styli (always back-to-front of course) and use an agent on them before every play, too. That cleaning system has worked very successfully for me for over 30 years. Records I purchased new back then are still silent after even 100+ plays in some cases. My styli also remain clean and show even wear when examined annually under magnification.
Kevin, there are several threads on the merits or lack thereof of just about every kind of record cleaning regime imaginable here. You'll have to come to your own conclusions about methodology, but cleaning of some kind before every play is generally considered a must-do. Dust is especially evil.