Your loft layout looks exactly like the one I use to live in. I put heavy roman shades on the windows and then a heavy curtain. It turned out beautifully and worked great.
I tried the angled in the corner thing but had too many problems with bass that way. Your layout is what worked best for me. The sound easily fills the whole loft this way. A couple nice tapestries, thick rugs or carpet, and some cloth furniture and you will be good to go.
I agree that direct radiating(cone) speakers will be the easiest to arrange in this space but with some additional planning I'm sure you could make most any speaker work for you.
I tried the angled in the corner thing but had too many problems with bass that way. Your layout is what worked best for me. The sound easily fills the whole loft this way. A couple nice tapestries, thick rugs or carpet, and some cloth furniture and you will be good to go.
I agree that direct radiating(cone) speakers will be the easiest to arrange in this space but with some additional planning I'm sure you could make most any speaker work for you.