Maybe I've been lucky, but I haven't had problems with fatiguing components, but I have gotten serious listeners fatigue from excessively bright ICs, speaker cables, digital cables, and worn out tubes in my SF pre-amp. I use and like Synergistic Research ICs and cables and use them throughout my system, but they have models such as Looking-glass ICs and Signature #3 cables that simply do not work in my system (tube pre-amp w/ SS amp), and definitely produced a brightness that caused significant listeners fatigue.
Some power cords will do it also, but I don't specifically remember the ones I didn't like. Auditioning wires in YOUR SYSTEM is essential to avoid this and other problems IMO.
In addition to excess brightness causing fatigue, an overly detailed, thin, analytical presentation will promote fatigue for me, but then these characteristics are also often related to excess upper mid-range and treble energy or brightness too. Cheers. Craig.