Hi. Like Twl mentioned, it could be an acoustical issue.
It certainly could be other issues causing the lack of focus and imaging. Perhaps power line issues, and you also may want to make sure not to run you power cords too close to interconnects and other cabling.
If that is not the issue, try re-positioning your speakers.
If you toe them in towards you, you can minimize first/second order reflections and reduce slap echo.
Also, sometimes when you move a system and cables, it takes a few days, maybe even weeks for everything to settle down again.
Sounds to me like you have some wild reflections going on though.
Also, you could have some doubling of certain frequencies, make sure your speaker positioning is not causing this.
There are plenty of good sources about room acoustics on the web, including the web sites of acoustical treatment companies.
There are also plenty of inexpensive ways to 'treat' your room.
Will post follow up if you wish..........
Hope this helps........