J River Vs. Media Monkey Do they sound different

So I invested in a Wyred 4 Sound Dac 2. Initially gad it hooked up to my Oppo 83 as transport and now have taken the plunge and hooked my PC up to the dac via USB. Very simple. Downloaded Media Moonkey and found it to be unnecessarily difficult to navigate. I downloaded J River and found the interface to be great.

I have Vista and am using Kernel Streaming. Sounds great! Even downloaded some hi res albums from HD Tracks. Does anyone have an opinion if there is a sound difference between the most popular packages and if so, who's software sounds the best? Are there software tricks that improve sound (besides kernel streaming and Wasapi?

Thanks in advance.