Is it possible to have to many tweeks in your system

I have tried a lot of tweeks in my system. Power cords, AC conditioning, isolation devices, racks, etc, etc.
I have found some to give an improvement in sound quality. Some just sound different and not better. And some just sound worse.

I am wondering is it possible to have to many tweeks in your system where one tweek cancels out the other. I have mostly heard that tweeks are a cumulative effort but I wonder in some situations can it have a negative effect?

Anything is possible.
I'm sure you can have multiple things cancel each other out- you know, like putting a humidifier and a dehumidifier in the same room and letting them fight it out 
One thing to avoid is having two suspensions under one component. For instance, an isolation platform with any kind of "spring" under a suspended turntable. But that you probably already know!
I scrupulously avoid lead and Sonex, myself. Two of the most heinous materials ever to be foisted upon naive gullible audiophiles. I’m not crazy about Sorbothane either. Ye olde ERS anti EMI/RFI cloth? Forget about it! You can overdo Tube Traps, crystals but you can never have too many Mpingo discs. But those empty beer bottles lying around will definitely mess you up.

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Sonex quickly "dissolves", ending up a crumbly, sticky, mess.
Yes, the tweakophile is in all of us and is doing quite well.  Can someone attest to the over-tweaked system?  

Walker resonance control discs have sealed lead in them. I don't see any problem with that. Too many of those discs would certainly make things worse. Lloyd himself warns about it and suggests experimenting.
Pretty sure both Lloyd and Pierre over at Mapleshade swore off lead a very long time ago. Pierre used a lot of lead in his set up for years. It seems like such a good idea, too.  :-;

Have you tried gold plating the beer cans? Works wonders.
Whether Sonex dissolves or doesn’t dissolve even having small sections of it anywhere in the room makes the sound all phasey and gnarly like.
Anything is possible.
There is always the distinct possibility of operator error.  One must be constantly vigilant.
Too much is never enough! Keep me posted & Happy Listening!