I have a similar sized room where i use Totem Sttaf speakers driven by SimAudio SS amp. The Totems seem to have no trouble reproducing tueful bass which can be a bit much in smaller spaces. Due to the furniture in your room, the tube amp and your listening tastes "bloomy" bass may not be a problem. I have hollow floors and am only able to move the speakers out 30". To combat any overwhelming bass i have stuck the speakers down with blu tack to two 12"x12" concrete slabs, then decoupled them using MDF cups and Oak balls which I picked up at Home Depot for under 12$. This helps tame the bloom considerably on the carpeted floor. I would recommend some sort of decoupling of these speakers; maybe an air platform on your hard wood. I have never tried to fill the bases of the Totems but you may want to experiment.
I found the speakers need no toe in when situated in large rooms but after moving to my current room (similar to yours) I gained best results when toeing them in to 5-10deg.
In regards to cabling; I currently use Cardas Neutral Reference IC and bi-wire Speaker cable. This produces extremely good results. Previously I tried Nordost Blue Heaven to less than spectacular results with my SS amp. If you contact Totem they will suggest you use their Tress and Sinew cables. I can only speak from a SS point of view but, don't do it! The sound was thin and underwhelming. You can do better! Also, I have heard other systems with Virtual Dynamics cables in the system and rather enjoyed the sound. Have fun.