I knew the question was 'general' in nature. My current system consists of an Audio Aero MkII CDP directly into a new Innersound power amp (300 watts into 8 / 600 into 4), that is driving a pair of Magnepan 3.6R's. I use a REL Storm III sub for the bottom end. All cabling is the new (and absolute killer, IMO) CRL 'Gold' series. My room is 15x19.
The maggies are fabulous speakers as long as you don't listen to anything with alot of bottom end or alot of dynamic swings, or anything with peaks of 85-90db. Everything else about them is good. So, I'm looking for something that I can listen to at higher levels... around 90db (or even greater when the mood dictates) without worrying that I'm going to blow them up! As I said, I want to be able to listen to everything from jazz to rock and roll. You simply can't do it with the maggies.
As far as amplification goes, I plan on purchasing an amp after I purchase the speakers that I like. In addition to the Innersound that I now have, I also own a Mark Levinson 334. Both SS, but I enjoy the virtues of tubes as well (I'm not one to get hung up on one is better than the other). That's why I plan on finding the right amp, after I find the right speakler system. If one of the two that I currently own works well, then so be it. If not, I'll find one that does.