I would say the sound gets a lot better after 50 hours and about 100 hours you are there.
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There is no "generally". I've used dozens of cartridges and their behavior from new varies all over the place. Some change very little, if at all. Others change profoundly and may not stabilize for 100-200 hours or (rarely) even longer. Most fall somewhere in between those extremes.
This unpredictability is true even between different models from the same manufacturer... more so as between one manufacturer and another.
The experiences of others with the CA Artist V2 (if anyone happens to share that) would give you some idea. Experiences with other cartridges would tell you almost nothing.