A vote here for MI2. I use it with my MartinLogans and am quite satisfied with the sound. Reasonable price for what you get.
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I am a dealer but I'm also a user of Goertz cables. The major difference between the Python line and the MI series flat cables is that the conductor size is smaller. If you want the same current capacity in a Python you have to move upstream to a MI3 design based Python.
In my humble opinion there is virtually no difference between them except durability of the cable; provided the same guage is used plus you also get a minor improvement in RF rejection due to the twist. Some folks prefer to wire them shotgun using one pair of MI2 flats for the high end and a larger Python for the bass connection. Either way they are a bargain in high end and compare well to cables three times their price.
The problem with the Python's is that they use a much lower grade of dielectric and a far greater quantity of it. The nominal impedance of the cable will also be slighlty different, especially if one tries to use the four conductors in a different wiring configuration. By staggering conductors or running identical polarities side by side, you could end up with two very different cables electrically. Sean