It's hard to answer. Having a full loom will maximize the positive effects, but also the negatives.
In my case I stayed for a long while with a full loom of a cable I adore, but ended up with an unnatural sounding system. Turns out having rhodium plugs everywhere wasn't such a good idea - in my system at least. I now have a mix of cables with the same wire materials and geometry but with gold plating after the source, silver plating between preamp and active crossover, rhodium before the amps, and it's much better. I'm about to try another gold cable between preamp and crossover and see where it brings me. Effects are cumulative. Voicing a system is like cooking.
YMMV, as always.