Depends on your digital hardware and software and your CD transport hardware. Whichever delivers the lower jitter and does not muck with the bits or the offset, that one will sound the best.
In general, off-the-shelf transports have higher jitter than that possible with digital hardware. This is particularly true if the digital is a low-jitter Ethernet interface. In fact, very few digital interfaces deliver this low jitter, but it is available if you know what to buy. USB is more problematic than Ethernet, but it can be excellent too.
Not that you cannot achieve low jitter with a Transport. All it takes is adding a reclocker to your Transport, like the Synchro-Mesh and you will have parity with the very best digital computer playback.
Steve N.
Empirical Audio