This is a great question and one I have been thinking about. I just switched from an all in one streamer/DAC/Preamp so no cabling involved to a lumin U2 into reimyo dac into SPL preamp all with Canare quad XLR cables.
I can not hear a diff. So if there should or should not be a diff I don't know but I am not hearing one. The main diff I have heard was switching DACs. I think you may hear a diff between say bluesound node and a lumin but could be noise reduction. The bits are perfect as they are so contamination from poor cables or constructed streamer components could cause a diff.
The lumin u2 is amazing. I was able to trade in the esoteric to Mike Kay (I have no affiliation and this is not an add so hope I don't get struck) but you get honest opinion on this topic as that is he forte.
Look forward to hearing more comments.
Best JH Love this stuff!