Not really, crossover design has more to do with it than number of drivers.
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Per Schubert, there is a distance at which a 1st order crossover theoretically maintains phase coherence - it will vary with the physical properties of the cabinet/drivers - but it's hard to otherwise generalize.
As to extreme near field use, single driver and/or concentric driver (see KEF uniQ) systems are one way to dance around the issue.
From my experience the ideal ratio for between speaker/from speaker distance is room size and speaker orientation driven. For many small room, long wall placement situations a near field approach may be ideal. The near field setting has the aforementioned ratio greater than 1. I also have found that the ideal ratio differs with recording, though an average ideal is what most of us strive for.
The many variables allow for divergent opinions.