Digital Interconnect Questions

I've always used inexpensive consumer grade digital cables of the $25 - $40 variety from Circus City, GoofGuys, etc. I'm talking about the 75ohm coaxial cable for attaching CD transport to DAC. Is there a significant difference in sound quality with higher-end digital interconnects? I've always been skeptical of over priced cables, especially the digital interconnect. I'm not seeking a debate but would like to know if anyone can actually hear a SIGNIFICANT difference. Thanks.