I did the used coax cable run a few years ago and found large differences. The one that stood out for me was a silnote coax. Wide, spacious and clear, although with a little less bass. Used coax cables are relatively cheap and resellable with no loss. I found it fun trying them out. I also got brand matching rca's, which together let's you learn about each brands house sound.
Digital coax cables
I stream Qobuz from a standalone streamer to a DAC. I use a digital coax cable [Audioquest cinnamon, about $90. Will one of the more expensive cables make much difference? Some claim no difference, it is before the DAC so it makes no difference. Others claim everything makes a difference. So......