Comparing Speaker Cables

I have accumulated several pairs of speaker cables that I have never tried to do careful A/B comparisons of because the time it takes to swap them is longer than my audio memory. But my speakers are bi-wired and it occurred to me that I could hook two different cables up and then only swap them at the amp which would be much faster. Is there any sonic downside to having a pair of unconnected cables hanging off one of the sets of inputs while the second set is connected to the amp?