Repositioning the fuse holder may have corrected problems with accessibility, but I doubt that would correct the issue of the fuse actually blowing.
it’s still not clear if the many fuse replacements are with this amp, or with all of your gear combined.
If it’s mostly the amp, then that indicates a problem.
Possibly the replacement is of the wrong rating (amperage; if you’re just replacing what was in there, then there’s a chance that the previous owner used a undersized fuse and you are repeating his mistake), or the wrong type (it may require a slow blow).
If most of the replacements were on that amp, and the correct replacements were used, then the amp has a problem and should be reviewed by someone that’s competent and preferably knowledgeable about that particular amp. In that case I’d say that it probably should be shipped back Ram Labs.
PS: Don’t beat yourself up too badly, learn the lesson and move on. Happiness is a choice, how do you want to spend the time you have left?