Both good but very different. V12 has a more liquid midrange and VS 110 has better base control and top end extension. Trade-off inherent in EL 34 vs 6550 and design philosophy. I have more exp. with VS 110; it is much improved with JJ KT88 in all aspect except cost and reliability of tubes. VS 110 is more neutral but V12 charm with female vocal and strng is difficult to ignore. Both amps more natural than many SS amps.