IMHO the loom has definiate advantages over the mix and match route. I recently completed a Kubala-Sosna loom and while I wasn't expecting the last addition to change much, I was pleasently suprised at how it pulled everything together.
Cable
There is a push at Nordost to push the idea of a cable "loom", all cables being the same, as the ideal in finding audio cable bliss. I am not convinced of this but am intrigued enough to start to question my system and my sanity, (as well as question my banker for a refinance on my car to pay for a new cable loom). Any experience out there of those who have tried the harmony of one brand/model of cable vs. the chaos of a mix of cables creating a sonic jungle.