Cable burn-in questions.

While burning in an interconnect cable, say the analogue output from a dac into a preamp, is it necessary for the preamp to be turned on? (I understand the answer would be “yes” if that input has not been used - to “break in” those circuits in the preamp.  But this question is focused on the cable.) Is current flowing through a cable when the preamp isn’t on?  Any reason why the amp connected to the preamp output must be on?  Does the volume on the preamp matter when a cable being burned in is connected to an input? 

  I assume speaker cables would need current and voltage passing through, to be burned in.  Does the volume setting matter?

    explanations for answers will be appreciated.