Thank you for your replys. Getting rid of the computer is sadly not an option, as i use it for music production and recording.
Ihave tried moving the soundcard and amplifier as far off as possible, with no change.
It is indeed an asus motherboard. However, i´m reluctant to replace it after replaceing the PSU to no avail. What makes me question is that i actually get rid of the interference when i connect my external soundcard to the active speaker instead of the amp. Any sugestions on how to troubleshoot this before investing in a new mobo?