I have done it both ways and both worked. I think much as you do, the central point for me is that the task is different for the wire carrying the bass signal than the higher frequencies. I am not a great fan of anitcable, especially on the bottom end. I would try a much heavier wire, or make one yourself. Take some magnet wire, which is similar to anti cable and use 6 or 8 strands twisted around each other with a very slow twist. Blue Jeans cable looks promising also but I haven't used it. There are arguments on both sides of this; I would just try something else on the bottom and see what you think.
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