You might want to try a pair of the new Allison Ones they are made to be placed directly against the wall or the Allison threes which are to be placed in the corners.
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Tough problem...You'll have major bass problems and imaging will be off potentially given your description. The only think I can think of would be a pair of Vandersteen Quatros or Model 5/5as. The main reason is that you'll need the bass sculpting ability they have. Plus, they won't be affected as much by the placement. Toe in and tilt will be critical too. Let us know what you end up with and how you like it please.
No firm decision as of yet, but I am doing a heck of a lot of research. I am leaning toward the Piega C10 Ltd, due to the fact it is "not" a rear ported design. Rather, it has 2 passive front bass radiators, affording me more near-wall placement leeway. Also, it is a relatively efficient design and is a taller speaker which would give me better vertical imaging, given my high ceiling.
If you can afford it, give the Eggleston Works, the AndraII a try. Slight toe in to enhance the image and can be placed close the rear wall. I have the same layout as your in my 2 story family room (20X24) Good luck. These speakers need a lot of power to make them sing. I driving my with the McCormack DNA500.