I've the Plinius is good but that they have reliability issues.
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I have been a Plnius dealer for close to two years and I have never seen a piece fail, so I don't know what Wireless is talking about.
The Plnius has a much warmer midrange with more punch that the Ayre which tends to be a clean slightly more drier sounding product.
So it comes down to a matter of taste.
I haven't heard about any reliability issues with Plinius. I have heard these two integrateds and sonically, they are quite different. Which you would prefer would depend on your tastes and associated equipment. I think the Ayre is more transparent, airier and neutral, while the Plinius is richer, warmer more vibrant. In the wrong system, the Ayre could sound clinical, while the Plinius could sound dark.
So 'will you be giving up anything?', I would say yes, but you would also be gaining something. Only you can decide if what you gain vs. what you give up is worthwhile.
I've owned the 8200mkII and now own the AX7e. I agree with Jmcgrogan2's opinion between the two. I do however think the Ayre is a higher quality, more accurate amp that provides more inner detail. It needs to be paired with components that bring the synergy you like.
It's tough to move up the Ayre line without selling your car.