Well sorta,but the bottom line is you're just adding another link in the chain,not to mention more cabling.If you're thinking tubes,consider a tube pre amp.
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I currently own the TB5.0 Tube Buffer and while it is true that it does not transform a solid state preamp into a reference qualilty tube preamp, it does provide a significant improvement in the the areas of tonal quality, harmonics, decay and general smoothness. As for the extra interconnects and circuitry, there is slight loss in detail and information but if you use good quality interconnects this loss is hard to hear. It has significantly improved every solid state preamp (X-1, ML380s, AVP-2, Krell, etc.) I have owned. It has made these preamps much more musical and enjoyable while still maintaining each of their strengths. Furthermore, with only two relatively inexpensive tubes to replace it is much less expensive to use over a long period than many highend tube preamps with multiple high cost tubes. In addition, this tube buffer sounds pretty good after only about 30 mins warm up time, while most tube preamps need hours if not days warm up to sound decent. I love the convience of my ML380s with remote control of volume, source switching and programing, etc. but wanted more tube warmth and naturalness and this Tube Buffer really delivered.
I own and use both the original Musical Fidelity and the V3 versions along with a Yaquin single tube version that I picked up in Hong Kong for cheap. I honestly think that they work wonders when used with most inexpensive CD/DVD players adding the depth and harmonics of a tube amp while at the same time eliminating any impedance mismatches between the units connected. It also works quite well with my Precision Fidelity C7a preamp which is essentially a tube phono preamp with a passive line stage so the buffer eliminates any cable length issues. Incidentally the Yaquin/Grant (basically the same unit) is the equal of the 1st generation Musical Fidelity performance wise.
I originally owned the Musical Fidelity X10v3 with outboard power supply and Revelation Audio umbilical cord. This added a bit a warmth and musicality in front of Channel Island D-200's ... which some have characterized as somewhat dry. The downside on the MF X10v3 is that it doesn't allow for tube rolling. There is no ability to tune or select tubes to complement your system.
I looked at the Grant B283 and Yaqin from Pacific Valve, settling on the Yaqin as it allows one to use NOS 6922 and 6DJ8 tubes. The Grant does not. Next, since I wanted to be sure of getting the right sound and the right equipment for MY system, I ordered the Yaqin and the Audio Horizons TB 5.0n at the same time. Bottom line ... it matters less what the most expert A-goner says about this because ultimately it's about YOUR system and your tastes. Both allow for a 30-day in-home audition with refund less nominal "restocking" fee (what a crock). Yeah, it's B.S. - but worth it if it helps make a decision free of looking back and second guessing. In the meantime, I boned up on tube information (Joe's Tube Lore is a good place to start).
It didn't take 30 days for me to determine that the AH TB 5.0n was the clearly superior product that justifies a significantly higher price than the Yaqin/Grant. I sold the MF X10v3 for a decent price and returned the Yaqin. Overall, I've been happy with the AH Tube Buffer. Of course, YMMV.