Are there any constants in speaker wire designs?

I've been looking at different speaker wires and the different designs and am wondering if anyone has listened to enough different speaker wires to know if there are any constants. Is there any "signature" sound that goes with similar designs? For example, does a four or eight wire braided (think Kimbel) have a particular sound quality compared to a basic two strand wire?

It seems that there should be some similarities amoung cables of similar design. The number of strands, braided vs. straight, gage, etc...

If there wasn't some truth to this it would mean that speaker wire designs are just random configurations.

Any thoughts?