DSD does tend to sound best from my Mytek DAC. But, I've not had too many (any?) opportunities to compare the same recording in both DSD and high res PCM where I could be certain that one wasn't just converted from the other.
The other night I compared "Like Minds" in 88/24 PCM from HDTracks to the DSD ripped directly from the SACD. The levels were nearly evenly matched, which made the comparison easy to do. The DSD was fuller sounding, with richer tones, and greater dimensionality. But it was very likely the case where the HDTracks version was converted from DSD - so not really a fair comparison of DSD to PCM.
I think ideally one should have the capability to play both DSD and PCM as music tends to be available on one format and not the other. Also something is lost when converting DSD to PCM, so it's best to play DSD natively.