I use JRiver Media Center. Great playback quality via USB to a DAC, links to other DLNA based services, plays just about any format you can think of. Relatively inexpensive licence. JRemote can be used to drive it all from iPad or iPhone. My Mac mini uses a wired connection which is rock solid.
Alternatives Software for iTunes on Mac
Been an iTunes user since its inception and quite satisfied with it with its overall sound quality in my system. Recently I have encountered some significant problems and have decided to look for an alternative to it. Have a large collection of music on a separate external hard drive in AIFF files, 2500 CDs or albums. Currently uses Apple airport express to wireless play music from my computer through a Rotes Integrated Amp and Monitor Audio Gold 100 speakers. I am looking for a high quality software to replace iTunes. I must to able to easy transfer existing files to the new software. Any suggestion would be appreciated.