Electrically, no difference. Monetarily, 100% more expensive for 2 runs. Aesthetically/street cred 2 runs are cooler. But if your real goal is the best sound, 1 run is as good as 2. Save yer money for stuff that really provides a benefit, like better source material and room tuning...
2 runs of wires or 1 run w/ jumpers
I am considering trying Anti Cables level 3 7' speaker wires. Am I better off using 1 set of wires with jumpers or running 2 sets of 7' wires?